Early plants began colonizing terrestrial Earth approximately 470 million years ago. Their success on land has been attributed to the evolution of a dazzling array of often lineage-specific, specialized metabolic traits, which serve as a means to cope with a myriad of ecological pressures. Our lab explores the origin and evolution of plant specialized metabolism at the enzyme, pathway, and systems levels. We have a broad interest in understanding the molecular mechanisms and functional implications underlying chemical interactions between plants and other organisms, including humans. Leveraging the fundamental knowledge learned from plant metabolism, we devise bioengineering strategies that enable innovative approaches to drug discovery, sustainable production of valuable medicinal and commodity chemicals, trait improvement in agricultural crops, and the development of climate remediation biotechnologies.